上皮粘连调控蛋白ESRP2抗体产品介绍

中文名称：上皮粘连调控蛋白ESRP2 多克隆抗体

英文名字：ESRP2 Polyclonal Antibody

供 应 商：远慕生物

背景资料：ESPR2 is an epithelial cell-type-specific splicing regulator. ESRP2 (Epithelial Splicing Regulatory Protein 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR2 and mRNA Capping.

宿主物种:兔

交叉反应:人,小鼠,大鼠,狗,奶牛

克隆类型:多克隆

分 子 量:78kDa

浓 度:1mg/1ml

亚 型:IgG

细胞定位:细胞核

免 疫 原:KLH conjugated synthetic peptide derived from human ESRP2

纯化方法:蛋白A亲和纯化

产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

尚未测试其他应用;

实际稀释浓度可根据用户的具体用途决定。

储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol

保存条件:4℃运输，-20℃保存，避免反复冻融

应用领域:细胞生物 细胞粘附分子 细胞类型标志物 表观遗传学

保存建议  自发货之日起，-20°C可稳定保存1年。为最大限度的避免损失，请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。

产品介绍

background:

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Function:

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Subcellular Location:

Nucleus.

Tissue Specificity:

Epithelial cell-specific.

Similarity:

Belongs to the ESRP family.

Contains 3 RRM (RNA recognition motif) domains.

Database links:

UniProtKB/Swiss-Prot: Q9H6T0.1

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.