平滑肌蛋白抗体说明书

Rabbit Anti-Smoothelin Polyclonal Antibody

平滑肌蛋白抗体

Size: 50ul

Concentration: 1mg/ml

Applications: WB(1:500-2000),ELISA(1:5000-10000),IHC-P(1:100-500),IHC-F(1:100-500),ICC(1:100-500),IF(1:100-500)

Cross Reactive Species: Human.Mouse.Rat.Dog.Pig.Cow.Rabbit.Orangutan.  

Host:  Rabbit

Target Protein:  Smoothelin

IR:  Immunogen Range:851-917/917

Clonality:  Polyclonal

Isotype:  IgG

Entrez Gene:  6525

Swiss Prot:  P53814

Source:  KLH conjugated synthetic peptide derived from human Smoothelin:851-917/917

Purification:  affinity purified by Protein A

Storage:  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The cytoskeletal protein smoothelin is highly conserved among vertebrates and is expressed exclusively by contractile smooth muscle cells where it localizes to the filament network. Smoothelin associates with actin stress fibers but does not interact with desmin. At least two isoforms of smoothelin are produced by alternative splicing. The short isoform lacks amino acids 1-544 at the amino-terminus of the long isoform. The short isoform is expressed in visceral muscle tissue, including intestine and stomach, but not in brain, while the long isoform is expressed in all vascularized organs. In the vascular system, smoothelin expression is limited to large veins and arteries capable of pulsatile contraction. As a marker for the highly differentiated contractile smooth muscle cell, smoothelin expression is useful for studying vascular malformation and injury. The gene encoding human smoothelin maps to chromosome 22q12.2.

For research use only. Not intended for diagnostic or therapeutic use.